After Ozempic, Meet NAD+: The Next Big Biohack

Move over, Ozempic. The latest wellness fix lighting up biohacking circles, fashion sets, and Hollywood group chats is NAD+—often delivered by IV drips, shots, or supplements.

From bed-bound to “back on”

When Moon Juice founder Amanda Chantal Bacon struggled with long-COVID fatigue, she says an hours-long IV of 500 mg NAD+ helped her turn a corner. She’s far from alone: celebrities and creators casually use “NAD” as a verb. Hailey Bieber joked she’ll “NAD forever,” Justin Bieber filmed himself getting a drip, Jennifer Aniston has praised weekly peptide shots, and Joe Rogan has compared a rushed NAD+ infusion to “your guts on fire.”

What NAD+ actually is

NAD+ (nicotinamide adenine dinucleotide) isn’t exotic—you already make it. It’s a coenzyme central to energy production, DNA repair, circadian rhythms, and stem-cell function. Your body builds NAD+ from vitamin B3 (niacin) and uses it in hundreds of biochemical reactions. Sleep, exercise, and B3-rich foods support levels, but aging and stress drive them down; by our 60s, average levels can be roughly half of those in our 20s, researchers note.

How people get it—and what experts debate

You’ll find NAD+ at luxury resorts and urban longevity clinics alike, offered as:

• IV infusions: intensive, time-consuming, and pricey (often ~$300–$2,000 per 500 mg). Going too fast can feel rough.
• Intramuscular shots: lower dose, faster and cheaper (often starting near $100).
• Supplements: typically NAD+ precursors such as NR (nicotinamide riboside) or NMN (nicotinamide mononucleotide).

Not all scientists agree on delivery. Some argue IV NAD+ itself is too large to enter cells efficiently and that precursors are the more biologically plausible route. Others use infusions for specific goals or short-term support.

The claims vs. the evidence

Fans credit NAD+ with everything from steadier energy and clearer thinking to better sleep, fat loss, and athletic edge. Rigorous human data are still emerging. Animal and early studies have shown encouraging signals (e.g., healthier aging markers in mice given NAD+ precursors), but large, definitive human trials are limited. Translation: interesting, not a miracle.

Where it may make sense

Doctors sometimes use NAD+ in targeted situations—post-operative recovery support, certain addiction protocols, or select neurological contexts—always with screening and supervision. Potential risks (including to kidney function) mean medical oversight matters, especially if you have underlying conditions or take other therapies.

Who’s using it

Longevity clinics report steady demand from “high performers”—athletes, entertainers, executives—who want to feel sharp for long days on set or stage. Some creatives time an IV or shot before big shoots or events to feel focused and steady.

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Bottom line: NAD+ is a real cellular coenzyme with a compelling biology story, buzzy marketing, and mixed but growing evidence. If you’re curious, start with fundamentals (sleep, training, nutrition, B3 intake), and if you go further, do it with a licensed clinician who can weigh risks, benefits, dose, and form.

Editor’s note: This is informational, not medical advice. Talk to your healthcare provider before starting NAD+ or any peptide therapy.